Allergens are often cosmetic and perfumery means, personal hygiene, household chemicals, causing allergic reactions in us and our children. In dentistry, allergic reactions can occur in the anesthetic, endodontic, filling, orthopedic materials. Allergens may be the active components of toothpastes, but more often they are the components of fragrances, surfactants and / or preservatives. Given the high prevalence of allergies, many cosmetics manufacturers use a special marking "Hypoallergenic". Among experts there is no consensus in the interpretation of the term, which is in a medical sense to mean the ability of funds specifically reduce allergic reactions, but most often used to indicate low risk of allergies. From this point of view, perhaps more correctly use the term "non-allergenic". Despite the fact that allergic diseases known to man more than two and a half thousand years, during the last century allergopatologii problem became especially acute. The concept of "allergy" was proposed in 1906 by Austrian pediatrician Von Pirquet to determine the change of state immunity as compared with those that should assume a "normal" people (1). In 1923 A.F. Coca and R.A. Cooke introduced the term "atopy" in order to highlight the concept of "abnormal" state of heightened sensitivity to various environmental factors (2). There are at least three circumstances which have made over the past decade, the problem of allergy in the global medical and social problem of our time. First, the prevalence of allergic diseases, affecting 30-40% of the population of the globe. Secondly, not only to subside, but the accelerating growth in the disease. Indeed, over the past 30 years, every decade the incidence of allergies worldwide has doubled. Thirdly, despite impressive achievements in the fundamental branches of biology and medicine, a better understanding of the nature of Allergy and creating new ways of antiallergic treatment and prevention for allergic diseases in recent years significantly heavier, which leads to an increase in temporary disability, disability in the population, reduce the quality of life ( 3). Virtually every doctor, regardless of specialty, often seen patients who have suspected or diagnosed allergic disease. If the patient's condition allows, he is referred for consultation to the allergist. However, in most cases the full range of diagnostic, therapeutic and preventive issues have to solve doctor. Of particular relevance is the problem of early childhood allergization. Allergic components often underlies the development of children serious dermatological, pulmonary, nephrological, gastrointestinal and other pathologies. The seriousness of the problem of child allergies is due to several factors. First, to date, proved a genetic predisposition to allergopatologiyam. And if one parent suffers from allergies, a child's allergy symptoms occur in 50% of cases. If both parents are allergic, a child falls ill in 75% of cases (4). Secondly, the known phenomenon of cross-allergy, when similar reactions are developed on an entirely different matter, other than the primary allergen. The basis of this phenomenon is the fact that the allergic reaction starts is not an allergen itself, but a particular piece of its molecule (etiotop), binds to specific receptors of immune cells, and sensitization develops in the substances with similar chemical groups (5). As a consequence, difficult to control flow of allergens from different sources, which may be any of the products, including toothpaste. Thirdly, the impact of adverse environmental factors weakened the protective functions of the Child, both postnatally and antenatally, which facilitates the penetration of allergen through histohematogenous barrier (6). Consequently, the main problem preventing the development of sensitization in children prone to allergic reactions - the restriction of access and the elimination of the allergen - becomes even more complicated. Statistics show that between 4% and 20% of children of European countries suffer from atopic dermatitis. The frequency of the disease is steadily increasing, which is associated with environmental degradation (7). Atopic dermatitis occur, usually quite early in the first year of life. It was at an early age is revealed dysfunction of various regulatory systems of the child, taking into account external trigger factors. Similar situation with diseases of the mouth, for example, often avtoznye stomatitis, heylity caused including allergic reactions. That is why the search and development of cosmetics, oral hygiene and household chemicals for children based on their ability to reduce or not to aggravate allergic reactions is an important task. The creators of children's products on the market of oral hygiene and cosmetology are willy-nilly "between Scylla and Charybdis" - efficiency and safety. The desire to create a highly effective tool with active ingredients are often at increased risk of side effects, especially allergic reaction. Putting the cornerstone maximum safety and low allergenicity, producers often receive "empty" product. The most rational way - conducting relevant research. The problem is finding an adequate and reliable criterion of an allergic child safety products - test hypoallergenic. The complexity of the problem is determined by the fact that the notion of hypoallergenic very conditional, as almost any natural or chemical agent may trigger allergic reactions in susceptible children. Unfortunately even the most sophisticated tests do not provide assurance of the absence of an allergic reaction in the individual patient, but they can predict its probability. Today, there are certified methodology for assessing the potential allergenicity of various compositions. Purpose of this study was to assess the evaluation of allergenic properties of toothpastes ROCKS for children and babies on an adequate model. It is known that in allergic diseases there is an increase in antibody levels class of immunoglobulin E (IgE). Allergic reactions developed as a result of the interaction of antibodies with the receptors basophils and mast cell degranulation c recent release of vasoactive amines, and that leads to inflammatory reactions resulting from the fixation of immune complexes in the skin. (8) This mechanism is based transport model with serum IgE allergen animal intact animal followed by administration of antigen and is called a passive cutaneous anaphylaxis / PKA / (9). Assessment of potential allergenicity of toothpastes ROCKS for children and babies was conducted in a test laboratory center FGI RNIITO them.